Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys.
Identifieur interne : 005164 ( Main/Exploration ); précédent : 005163; suivant : 005165Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys.
Auteurs : Josephine Mcauliffe [États-Unis] ; Leatrice Vogel ; Anjeanette Roberts ; Gary Fahle ; Steven Fischer ; Wun-Ju Shieh ; Emily Butler ; Sherif Zaki ; Marisa St Claire ; Brian Murphy ; Kanta SubbaraoSource :
- Virology [ 0042-6822 ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Antigènes viraux (analyse), Appareil respiratoire (virologie), Bronches (virologie), Macaca fascicularis, Macaca mulatta, Muqueuse respiratoire (virologie), Réplication virale (physiologie), Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (isolement et purification), Virus du SRAS (physiologie).
- MESH :
- analyse : Antigènes viraux.
- anatomopathologie : Syndrome respiratoire aigu sévère.
- isolement et purification : Virus du SRAS.
- physiologie : Réplication virale, Virus du SRAS.
- virologie : Appareil respiratoire, Bronches, Muqueuse respiratoire, Syndrome respiratoire aigu sévère.
- Animaux, Macaca fascicularis, Macaca mulatta.
English descriptors
- KwdEn :
- Animals, Antigens, Viral (analysis), Bronchi (virology), Chlorocebus aethiops, Macaca fascicularis, Macaca mulatta, Respiratory Mucosa (virology), Respiratory System (virology), SARS Virus (isolation & purification), SARS Virus (physiology), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology), Virus Replication (physiology).
- MESH :
- chemical , analysis : Antigens, Viral.
- isolation & purification : SARS Virus.
- pathology : Severe Acute Respiratory Syndrome.
- physiology : SARS Virus, Virus Replication.
- virology : Bronchi, Respiratory Mucosa, Respiratory System, Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Macaca fascicularis, Macaca mulatta.
Abstract
SARS coronavirus (SARS-CoV) administered intranasally and intratracheally to rhesus, cynomolgus and African Green monkeys (AGM) replicated in the respiratory tract but did not induce illness. The titer of serum neutralizing antibodies correlated with the level of virus replication in the respiratory tract (AGM>cynomolgus>rhesus). Moderate to high titers of SARS-CoV with associated interstitial pneumonitis were detected in the lungs of AGMs on day 2 and were resolving by day 4 post-infection. Following challenge of AGMs 2 months later, virus replication was highly restricted and there was no evidence of enhanced disease. These species will be useful for the evaluation of the immunogenicity of candidate vaccines, but the lack of apparent clinical illness in all three species, variability from animal to animal in level of viral replication, and rapid clearance of virus and pneumonitis in AGMs must be taken into account by investigators considering the use of these species in efficacy and challenge studies.
DOI: 10.1016/j.virol.2004.09.030
PubMed: 15527829
Affiliations:
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Le document en format XML
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The titer of serum neutralizing antibodies correlated with the level of virus replication in the respiratory tract (AGM>cynomolgus>rhesus). Moderate to high titers of SARS-CoV with associated interstitial pneumonitis were detected in the lungs of AGMs on day 2 and were resolving by day 4 post-infection. Following challenge of AGMs 2 months later, virus replication was highly restricted and there was no evidence of enhanced disease. These species will be useful for the evaluation of the immunogenicity of candidate vaccines, but the lack of apparent clinical illness in all three species, variability from animal to animal in level of viral replication, and rapid clearance of virus and pneumonitis in AGMs must be taken into account by investigators considering the use of these species in efficacy and challenge studies.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Butler, Emily" sort="Butler, Emily" uniqKey="Butler E" first="Emily" last="Butler">Emily Butler</name><name sortKey="Fahle, Gary" sort="Fahle, Gary" uniqKey="Fahle G" first="Gary" last="Fahle">Gary Fahle</name><name sortKey="Fischer, Steven" sort="Fischer, Steven" uniqKey="Fischer S" first="Steven" last="Fischer">Steven Fischer</name><name sortKey="Murphy, Brian" sort="Murphy, Brian" uniqKey="Murphy B" first="Brian" last="Murphy">Brian Murphy</name><name sortKey="Roberts, Anjeanette" sort="Roberts, Anjeanette" uniqKey="Roberts A" first="Anjeanette" last="Roberts">Anjeanette Roberts</name><name sortKey="Shieh, Wun Ju" sort="Shieh, Wun Ju" uniqKey="Shieh W" first="Wun-Ju" last="Shieh">Wun-Ju Shieh</name><name sortKey="St Claire, Marisa" sort="St Claire, Marisa" uniqKey="St Claire M" first="Marisa" last="St Claire">Marisa St Claire</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Mcauliffe, Josephine" sort="Mcauliffe, Josephine" uniqKey="Mcauliffe J" first="Josephine" last="Mcauliffe">Josephine Mcauliffe</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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